Sean Wiley was born in Erie, Pennsylvania, on March 16, 1971. He attended Fairview High School and graduated in 1989. He continued his studies at DeVry University in Columbus, Ohio, and achieved a bachelor's degree in Business Operations, graduating in 1993.
Wiley first ran for office in the 2012 election for Pennsylvania Senate District 49. The incumbent Jane Earll (R) did not seek re-election.
He assumed office on January 1, 2013. On November 8, 2016, Wiley lost his re-election bid to Dan Laughlin.
Wiley lives in Erie County, Pennsylvania.