PRINTER'S NO. 3325
THE GENERAL ASSEMBLY OF PENNSYLVANIA
HOUSE RESOLUTION
No.
754
Session of
2020
INTRODUCED BY FLYNN, HOWARD, BIZZARRO, KORTZ, HENNESSEY,
DONATUCCI, LONGIETTI, MURT, PASHINSKI, YOUNGBLOOD, BURNS,
KOSIEROWSKI, MILLARD, READSHAW, BERNSTINE, FREEMAN,
McCLINTON, NEILSON, KIM, SCHLEGEL CULVER, ROZZI AND GAINEY,
FEBRUARY 24, 2020
REFERRED TO COMMITTEE ON HUMAN SERVICES, FEBRUARY 24, 2020
A RESOLUTION
Designating April 16, 2020, as "4p-/Wolf-Hirschhorn Syndrome
Awareness Day" in Pennsylvania.
WHEREAS, 4p- syndrome occurs due to a chromosomal deletion on
the short arm of chromosome 4, resulting in various physical
anomalies and developmental delays; and
WHEREAS, 4p- syndrome can result in Wolf-Hirschhorn syndrome,
identifiable by distinct facial characteristics, cognitive and
physical development delays and intellectual disabilities; and
WHEREAS, The secondary medical complications associated with
4p- syndrome, such as congestive heart disease, pneumonia due to
a weak chest wall and uncontrollable seizures, lead to the
difficulty of caring for an individual with Wolf-Hirschhorn
syndrome; and
WHEREAS, The prevalence of Wolf-Hirschhorn syndrome is
estimated to be 1 in every 50,000 births and, for an unknown
reason, females are twice as likely as males to be born with
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4p- syndrome; and
WHEREAS, The size of the genetic material deletion on
chromosome 4 is suggested to affect the severity of signs and
symptoms of Wolf-Hirschhorn syndrome; and
WHEREAS, Between 85% and 95% of all cases of Wolf-Hirschhorn
syndrome are not inherited, but rather are caused by a random
event during the formation of reproductive cells; and
WHEREAS, The average life expectancy for those with Wolf-
Hirschhorn syndrome is not well-defined; and
WHEREAS, The long-term prognosis for people who are born with
4p- syndrome depends on the severity of the case; and
WHEREAS, Because the fourth chromosome deleted is named
4p16.3, the date April 16 (4/16) has been chosen to bring
awareness to this genetic condition; therefore be it
RESOLVED, That the House of Representatives designate April
16, 2020, as "4p-/Wolf-Hirschhorn Syndrome Awareness Day" in
Pennsylvania.
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